Sodium Hydroxide → HCID 178461614, compound

HRID 2108220Notes

Reaction equation

HRID 2108220 reaction equation
[PH:1](=[O:13])([O-:12])[O:2][C@@H:3]([O:7]S(C)(=O)=O)[C@@H:4](O)[CH3:5].[Na+:14].[Na+].O[C@@H:17]([CH3:28])[C@@H:18]([O:24][PH:25](=[O:27])[O-:26])[O:19]S(C)(=O)=O.[OH-].[Na+]>O>[PH:1](=[O:13])([O-:12])[O:2][C@H:3]1[O:7][C@H:4]1[CH3:5].[Na+:14].[Na+:14].[O:19]1[C@@H:17]([CH3:28])[C@H:18]1[O:24][PH:25](=[O:27])[O-:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178462350HCID 178462350, compound

Product 1

HCID 178461614HCID 178461614, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of disodium (1S,2S)-2-hydroxy-1-methanesulphonyloxypropyl phosphonate (2.78 g) in water (10 ml) an aqueous solution 1N of sodium hydroxide (10 ml, 10 mmol) was added at 15° C. The reaction mixture was kept at 15° C. for 2 hours. Evaporation of the solvent affords disodium (1R,2S)-1,2-epoxypropyl phosphonate.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-728f6ad6a6bf4978b38d3b78a01d8cce
Source dataset
uspto-grants-1990_06
Patent number
US04937367

Reaction notes

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