4,4,4-Trifluoro-1-(m-tolyl)butane-1,3-dione → HCID 67213403, compound

HRID 2108392Notes

Reaction equation

HRID 2108392 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])[CH:5]=[CH:6][CH:7]=1.[NH2:17][C:18]1[C:22]([C:23]#[N:24])=[CH:21][NH:20][N:19]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:19]3[N:20]=[CH:21][C:22]([C:23]#[N:24])=[C:18]3[N:17]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 186240994,4,4-Trifluoro-1-(m-tolyl)butane-1,3-dioneHCID 178510443HCID 178510443, compound

Product 1

HCID 67213403HCID 67213403, compoundYield 54.3%

Procedure

Reaction of 1-(3-methyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (230 mg, 1.0 mmol), prepared from commercially available 3-methyl-acetophenone according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (164 mg, 54%). MS (ISP) 303.2 [(M+H)+]; mp 202° C.

Sources & evidence

ORD record
ord-fb020c6ca5dc4368a757940448321bef
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

Loading…