2-Fluoro-1-phenylethan-1-one → HCID 67212987, compound

HRID 2108398Notes

Reaction equation

HRID 2108398 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12].FCC(C1C=CC=CC=1)=O.[NH2:27][C:28]1[C:32]([C:33]#[N:34])=[CH:31][NH:30][N:29]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:29]2[N:30]=[CH:31][C:32]([C:33]#[N:34])=[C:28]2[N:27]=1

Participants

4

Reactant 3

HCID 99472-Fluoro-1-phenylethan-1-oneHCID 431869194,4,4-trifluoro-1-(2-fluorophenyl)butane-1,3-dioneHCID 178510443HCID 178510443, compound

Product 1

HCID 67212987HCID 67212987, compoundYield 27.1%

Procedure

Reaction of 1-(2-fluoro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (234 mg, 1.0 mmol), prepared from commercially available 2-fluoro-acetophenone according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a light yellow solid (83 mg, 27%). MS (ISP) 307.1 [(M+H)+]; mp 165° C.

Sources & evidence

ORD record
ord-da7c7c6ec23343dfa0de031e32b0cf8a
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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