3-amino-5-methyl-1H-pyrazole-4-carbonitrile → HCID 67213296, compound

HRID 2108410Notes

Reaction equation

HRID 2108410 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])=[CH:4][CH:3]=1.[NH2:17][C:18]1[C:22]([C:23]#[N:24])=[C:21]([CH3:25])[NH:20][N:19]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:19]3[N:20]=[C:21]([CH3:25])[C:22]([C:23]#[N:24])=[C:18]3[N:17]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2274603-amino-5-methyl-1H-pyrazole-4-carbonitrileHCID 27738321-(4-Chlorophenyl)-4,4,4-trifluorobutane-1,3-dione

Product 1

HCID 67213296HCID 67213296, compoundYield 66%

Procedure

Reaction of 1-(4-chloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (251 mg, 1.0 mol), prepared from commercially available 4-chloro-acetophenone according to general procedure A, and commercially available 3-amino-4-cyano-5-methyl-pyrazole (122 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (222 mg, 66%). MS (ISP) 337.1 [(M+H)+]; mp 238° C.

Sources & evidence

ORD record
ord-0d97937c7a9c491f818830f2d263d9c3
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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