Acetophenone → HCID 11196973, compound

HRID 2108471Notes

Reaction equation

HRID 2108471 reaction equation
[C:1]1([C:7](=O)[CH2:8][C:9](=O)[C:10]([F:13])([F:12])[F:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(C1C=CC=CC=1)(=O)C.[NH2:25][C:26]1[N:27]=[CH:28][NH:29][C:30]=1[C:31]#[N:32]>>[C:1]1([C:7]2[CH:8]=[C:9]([C:10]([F:13])([F:12])[F:11])[N:27]3[CH:28]=[N:29][C:30]([C:31]#[N:32])=[C:26]3[N:25]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 7410AcetophenoneHCID 675894,4,4-Trifluoro-1-phenyl-1,3-butanedioneHCID 787775-amino-1H-imidazole-4-carbonitrile

Product 1

HCID 11196973HCID 11196973, compoundYield 37.1%

Procedure

Reaction of 1-phenyl-4,4,4-trifluoro-butane-1,3-dione (216 mg, 1.0 mmol), prepared from commercially available acetophenone according to general procedure A, and 4-amino-5-cyano-1H-imidazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (107 mg, 37%). MS (ISP) 289.0 [(M+H)+]; mp 202° C.

Sources & evidence

ORD record
ord-0a8272c4eb6645159e31a236deaf35d3
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

Loading…