1-Phenyl-1-propanone → HCID 67213025, compound

HRID 2108478Notes

Reaction equation

HRID 2108478 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12].CCC(C1C=CC=CC=1)=O.[NH2:27][C:28]1[N:29]=[CH:30][NH:31][C:32]=1[C:33]#[N:34]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:29]2[CH:30]=[N:31][C:32]([C:33]#[N:34])=[C:28]2[N:27]=1

Participants

4

Reactant 3

HCID 71481-Phenyl-1-propanoneHCID 787775-amino-1H-imidazole-4-carbonitrileHCID 157720214,4,4-Trifluoro-1-(2-methylphenyl)butane-1,3-dione

Product 1

HCID 67213025HCID 67213025, compoundYield 6.3%

Procedure

Reaction of 1-(2-methyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (230 mg, 1.0 mmol), prepared from commercially available 2-methyl-acetophenone according to general procedure A, and 4-amino-5-cyano-1H-imidazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (19 mg, 6%). MS (ISP) 303.0 [(M+H)+]; mp 151° C.

Sources & evidence

ORD record
ord-1f44ad8efd3a4194a093496492a43965
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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