Hydrochloric Acid → HCID 66669797, compound

HRID 2108494Notes

Reaction equation

HRID 2108494 reaction equation
C(N1CC=C(C2C3C(=CC(C(N4CCN(C(C)C)CC4)=O)=CC=3)NC=2)CC1)C(C)C.Cl.[NH:32]1[C:40]2[C:35](=[CH:36][CH:37]=[C:38]([C:41]([OH:43])=[O:42])[CH:39]=2)[CH:34]=[CH:33]1.[CH2:44]([N:51]1[CH2:56][CH2:55][C:54](=O)[CH2:53][CH2:52]1)[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1>>[CH2:44]([N:51]1[CH2:52][CH:53]=[C:54]([C:34]2[C:35]3[C:40](=[CH:39][C:38]([C:41]([OH:43])=[O:42])=[CH:37][CH:36]=3)[NH:32][CH:33]=2)[CH2:55][CH2:56]1)[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 192201-Benzyl-4-piperidoneHCID 5952301H-indole-6-carboxylic acidHCID 25178886HCID 25178886, compound

Product 1

HCID 66669797HCID 66669797, compound

Procedure

According to the procedure described for the synthesis of [3-(1-isobutyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indol-6-yl]-(4-isopropyl-piperazin-1-yl)-methanone; hydrochloride (Example 1; step 2) the title compound was prepared from indole-6-carboxylic acid (commercially available) and 1-benzyl-4-piperidone (commercially available). MS (m/e): 333.2 (MH+).

Sources & evidence

ORD record
ord-7bab86997b8b49f1ace12391b35c5c5b
Source dataset
uspto-grants-2009_04
Patent number
US07514433B2

Reaction notes

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