Hydrochloric Acid → HCID 68563818, compound

HRID 2108499Notes

Reaction equation

HRID 2108499 reaction equation
[CH2:1]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[C:19]3[C:14](=[CH:15][C:16]([C:20]([N:22]4[CH2:27][CH2:26][N:25]([CH:28]([CH3:30])[CH3:29])[CH2:24][CH2:23]4)=[O:21])=[CH:17][CH:18]=3)[N:13]([CH3:31])[CH:12]=2)[CH2:7][CH2:6]1)[CH:2]([CH3:4])[CH3:3].Cl.[CH2:33](N1CCC(C2C3C(=CC(C(N4CCN(C(C)C)CC4)=O)=CC=3)NC=2)CC1)[CH:34](C)[CH3:35].ICC(C)C>>[CH2:31]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[C:16]([C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH:28]([CH3:30])[CH3:29])[CH2:24][CH2:23]3)=[O:21])[CH:15]=2)[C:11]([CH:8]2[CH2:7][CH2:6][N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[CH2:10][CH2:9]2)=[CH:12]1)[CH:34]([CH3:35])[CH3:33]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 10556Isobutyl iodideHCID 24783268HCID 24783268, compoundHCID 68560856HCID 68560856, compound

Product 1

HCID 68563818HCID 68563818, compound

Procedure

According to the procedure described for the synthesis of [3-(1-isobutyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1-methyl-1H-indol-6-yl]-(4-isopropyl-piperazin-1-yl)-methanone; hydrochloride (example 42) the title compound was prepared from [3-(1-isobutyl-piperidin-4-yl)-1H-indol-6-yl]-(4-isopropyl-piperazin-1-yl)-methanone (example 2, free base) and 1-iodo-2-methylpropane (commercially available). MS (m/e): 467.5 (MH+).

Sources & evidence

ORD record
ord-c423029aadf6461fb66fe245d6c5d7c3
Source dataset
uspto-grants-2009_04
Patent number
US07514433B2

Reaction notes

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