Hydrochloric Acid → HCID 68561885, compound

HRID 2108500Notes

Reaction equation

[CH2:1]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[C:19]3[C:14](=[CH:15][C:16]([C:20]([N:22]4[CH2:27][CH2:26][N:25]([CH:28]([CH3:30])[CH3:29])[CH2:24][CH2:23]4)=[O:21])=[CH:17][CH:18]=3)[N:13](C)[CH:12]=2)[CH2:7][CH2:6]1)[CH:2]([CH3:4])[CH3:3].Cl.C(N1CCC(C2C3C(=CC(C(N4CCN(C(C)C)CC4)=O)=CC=3)NC=2)CC1)C(C)C.[CH3:63][S:64](Cl)(=[O:66])=[O:65]>>[CH2:1]([N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[C:19]3[C:14](=[CH:15][C:16]([C:20]([N:22]4[CH2:27][CH2:26][N:25]([CH:28]([CH3:30])[CH3:29])[CH2:24][CH2:23]4)=[O:21])=[CH:17][CH:18]=3)[N:13]([S:64]([CH3:63])(=[O:66])=[O:65])[CH:12]=2)[CH2:7][CH2:6]1)[CH:2]([CH3:4])[CH3:3]

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 31297Methanesulfonyl chloride

HCID 24783268HCID 24783268, compound

HCID 68560856HCID 68560856, compound

Product 1

HCID 68561885HCID 68561885, compound

Procedure

According to the procedure described for the synthesis of [3-(1-isobutyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1-methyl-1H-indol-6-yl]-(4-isopropyl-piperazin-1-yl)-methanone; hydrochloride (example 42) the title compound was prepared from [3-(1-isobutyl-piperidin-4-yl)-1H-indol-6-yl]-(4-isopropyl-piperazin-1-yl)-methanone (example 2, free base) and methanesulfonylchloride (commercially available). MS (m/e): 489.2 (MH+).

Sources & evidence

ORD record: ord-50a916b2fe2a4d3fb8a42a5d21ba2f50
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07514433B2

Reaction notes

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