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HRID2108706

反应详情

EQUATION

反应方程式

HRID 2108706 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)[C@H](CC(C)C)N[C@@H](C(=O)Nc1ccccc1OCc1ccccc1)c1ccc2occc2c1
HCID45076860

N-[(1R)-1-(5-Benzofuranyl)-2-oxo-2-[[2-(phenylmethoxy)phenyl]amino]ethyl]-L-leucine methyl ester

C30H32N2O5

PRODUCTS

生成物

1
结构：COC(=O)[C@H](CC(C)C)N[C@@H](C(=O)Nc1ccccc1O)c1ccc2occc2c1
HCID45076859

未命名化合物

收率 82%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A mixture of palladium on carbon (10%, 500 mg), methyl N-[(1R)-2-{[2-(benzyloxy)phenyl]amino}-1-(benzofuran-5-yl)-2-oxoethyl]-L-leucinate (5.1 g) and ethyl acetate (60 ml) was stirred under a hydrogen atmosphere for 5 hours. The reaction was then filtered through Celite and the filter pad was washed with further portions of ethyl acetate. The combined organic fractions were evaporated to give methyl N-{(1R)-1-(benzofuran-5-yl)-2-[(2-hydroxyphenyl)amino]-2-oxoethyl}-L-leucinate (3.429 g).

WORKUP

后处理

  1. filtrationThe reaction was then filtered through Celite
  2. washthe filter pad was washed with further portions of ethyl acetate
  3. customThe combined organic fractions were evaporated