1-(2-Aminobenzothiazol-6-yl)-3-(4-chloro-3-trifluoromethylphenyl)urea → 1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[2-(7-hydroxy-6-methoxy-quinazolin-4-ylamino)-benzothiazol-6-yl]-urea

HRID 2108924Notes

Reaction equation

HRID 2108924 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:14])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:15][C:16]1[S:17][C:18]2[CH:24]=[C:23]([NH:25][C:26]([NH:28][C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[C:31]([C:36]([F:39])([F:38])[F:37])[CH:30]=3)=[O:27])[CH:22]=[CH:21][C:19]=2[N:20]=1>>[Cl:35][C:32]1[CH:33]=[CH:34][C:29]([NH:28][C:26]([NH:25][C:23]2[CH:22]=[CH:21][C:19]3[N:20]=[C:16]([NH:15][C:2]4[C:11]5[C:6](=[CH:7][C:8]([OH:14])=[C:9]([O:12][CH3:13])[CH:10]=5)[N:5]=[CH:4][N:3]=4)[S:17][C:18]=3[CH:24]=2)=[O:27])=[CH:30][C:31]=1[C:36]([F:38])([F:37])[F:39]

Participants

3

Reactant 2

HCID 231325021-(2-Aminobenzothiazol-6-yl)-3-(4-chloro-3-trifluoromethylphenyl)ureaHCID 1357422514-Chloro-6-methoxyquinazolin-7-ol

Product 1

HCID 1360721651-(4-Chloro-3-trifluoromethyl-phenyl)-3-[2-(7-hydroxy-6-methoxy-quinazolin-4-ylamino)-benzothiazol-6-yl]-urea

Procedure

1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[2-(7-hydroxy-6-methoxy-quinazolin-4-ylamino)-benzothiazol-6-yl]-urea was prepared according to GP 1 starting from 4-Chloro-6-methoxy-quinazolin-7-ol and intermediate 3.

Sources & evidence

ORD record
ord-87828a0469dd4f6d9ed91e18523f538c
Source dataset
uspto-grants-2009_04
Patent number
US07514460B2

Reaction notes

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