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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2108924Generated: October 30, 2026

1-(2-Aminobenzothiazol-6-yl)-3-(4-chloro-3-trifluoromethylphenyl)urea → 1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[2-(7-hydroxy-6-methoxy-quinazolin-4-ylamino)-benzothiazol-6-yl]-urea

https://huagongshe.com/reaction/2108924

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Aminobenzothiazol-6-yl)-3-(4-chloro-3-trifluoromethylphenyl)ureaHCID 23132502—
Reactant4-Chloro-6-methoxyquinazolin-7-olHCID 135742251—
Product1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[2-(7-hydroxy-6-methoxy-quinazolin-4-ylamino)-benzothiazol-6-yl]-ureaHCID 136072165—

Reaction Steps

1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[2-(7-hydroxy-6-methoxy-quinazolin-4-ylamino)-benzothiazol-6-yl]-urea was prepared according to GP 1 starting from 4-Chloro-6-methoxy-quinazolin-7-ol and intermediate 3.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07514460B2
Source datasetuspto-grants-2009_04
ORD IDord-87828a0469dd4f6d9ed91e18523f538c
Source noteuspto-grants-2009_04