Benzyl Chloride → 2-Benzyl-3-(4-methylphenyl)-2H-indazole

HRID 2108998Notes

Reaction equation

HRID 2108998 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.CC[O-].[Na+].[CH2:21](Cl)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH2:21]([N:9]1[C:8]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=2)=[C:16]2[C:11]([CH:12]=[CH:13][CH:14]=[CH:15]2)=[N:10]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 7503Benzyl ChlorideHCID 2723922Sodium ethoxideHCID 98777323-(4-methylphenyl)-1H-indazole

Product 1

HCID 115222532-Benzyl-3-(4-methylphenyl)-2H-indazoleYield 5%

Procedure

Compound 10 (6.24 g, 0.03 mol), EtONa (4.08 g, 0.06 mol) and benzyl chloride (10.18 g, 0.08 mol) were allowed to react as in the preparation of compound 15 to afford compound 26 (0.45 g, 5%).

Sources & evidence

ORD record
ord-6e4388aeb2994944ba8f9396f2042b5f
Source dataset
uspto-grants-2009_04
Patent number
US07514465B2

Reaction notes

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