Ethanol → Choline

HRID 2108999Notes

Reaction equation

HRID 2108999 reaction equation
[C:1]([C:3]1[N:7]([CH3:8])[C:6](C2C=C3C(=CC=2)NC(=NC#N)C23CCCCC2)=[CH:5]C=1)#N.[CH2:26]([OH:28])[CH3:27]>>[OH:28][CH2:26][CH2:27][N+:7]([CH3:8])([CH3:3])[CH3:6].[NH:7]([CH2:3][CH3:1])[CH2:6][CH3:5]

Participants

4

Reactant 2

HCID 702EthanolHCID 178480854HCID 178480854, compound

Product 2

HCID 305CholineHCID 8021Diethylamine

Procedure

5′-(5-Cyano-1-methyl-1H-pyrrol-2-yl)spiro[cyclohexane-1,3′-[3H]indol]-2′-ylidenecyanamide (0.96 g) in ethanol (20 mL) was reacted with the bases set forth in Table 2 to form, upon cooling, filtering and drying, 5′-(5-cyano-1-methyl-1H-pyrrol-2-yl)spiro[cyclohexane-1,3′-[3H]indol]-2′-ylidenecyanamide salt as a solid. The 1H-NMR spectra (DMSO-d6) of the purified compound (X═H) and isolated salts (X═Na, K, choline, and Et2NH.H) were obtained and the data compiled in Table 2.

Workup

  1. customto form
  2. temperatureupon cooling
  3. filtrationfiltering
  4. customdrying

Sources & evidence

ORD record
ord-862c0404c63844b7994f7f4694d45717
Source dataset
uspto-grants-2009_04
Patent number
US07514466B2

Reaction notes

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