Hydrazine hydrate (1:1) → HCID 67243107, compound

HRID 2109002Notes

Reaction equation

HRID 2109002 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([F:12])[C:3]=1F.O.[NH2:15][NH2:16]>C(O)C>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([F:12])[C:3]=1[NH:15][NH2:16]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27770141,2,3-trifluoro-5-(trifluoromethyl)benzene

Product 1

HCID 67243107HCID 67243107, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1,2,3-trifluoro-5-(trifluoromethyl)benzene (300 g, 1.5 mmol) and hydrazine monohydrate (300 g, 6.0 mmol) in ethanol (1200 ml) was heated at reflux overnight. The reaction mixture was concentrated in vacuo and the residue was re-crystallised from 2-propanol to give Preparation 21 (194 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationThe reaction mixture was concentrated in vacuo
  4. customthe residue was re-crystallised from 2-propanol
  5. customto give

Sources & evidence

ORD record
ord-b3160c253a1e40b893d632a2e45dce21
Source dataset
uspto-grants-2009_04
Patent number
US07514464B2

Reaction notes

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