1-Chloro-2-(diethylamine)ethane hydrochloride → HCID 69065330, compound

HRID 2109022Notes

Reaction equation

HRID 2109022 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([OH:13])=[O:12])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[OH-].[Na+].[CH3:16][CH2:17][N:18]([CH2:21][CH2:22]Cl)[CH2:19][CH3:20].Cl>O>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([S:11]([CH2:16][CH2:17][N:18]([CH2:21][CH3:22])[CH2:19][CH3:20])(=[O:13])=[O:12])=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 14798Sodium Hydroxide2×HCID 4121504-(Acetylamino)benzenesulfinic acid

Product 1

HCID 69065330HCID 69065330, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9.0 g of 4-acetamido-phenylsulphinic acid are dissolved in 10 ml of water and 45 ml of 1N sodium hydroxide solution and 9.47 g of 2-chlorotriethylamine hydrochloride are added. The mixture is stirred for 5 hours at reflux temperature. After cooling, sodium hydroxide solution is added until an alkaline reaction is obtained, the mixture is extracted with ethyl acetate, dried over magnesium sulphate and finally the solvent is eliminated.

Workup

  1. temperatureat reflux temperature
  2. temperatureAfter cooling
  3. customis obtained
  4. extractionthe mixture is extracted with ethyl acetate
  5. dry with materialdried over magnesium sulphate

Sources & evidence

ORD record
ord-d6396b351f864c0abea1e4bff9a0de9c
Source dataset
uspto-grants-2009_04
Patent number
US07514468B2

Reaction notes

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