反应详情

温度

120 °C

6.0 g of 1-acetyl-3-(1-ethoxy-1-phenylmethylen)-6-chloro-2-indolinone (educt IX) and 3.9 g of N-(dimethylcarbamoylmethyl)-p-phenylenediamine (educt XV.208) are dissolved in 50 ml of dimethylformamide and stirred for 4.5 hours at 120° C. After cooling water is added, the precipitate formed is suction filtered and washed with methanol. The product is purified through a silica gel column with methylene chloride/methanol (100:1) as eluant and finally recrystallised from ether.

1. additionis added
2. customthe precipitate formed
3. filtrationfiltered
4. washwashed with methanol
5. customThe product is purified through a silica gel column with methylene chloride/methanol (100:1) as eluant
6. customfinally recrystallised from ether