Hydrochloric Acid → HCID 178517233, compound

Participants

Reaction Conditions

Reaction Steps

450 mg of 3-Z-[1-(4-ethoxycarbonyl-anilino)-1-phenyl-methylene]-6-chloro-2-indolinone (educt 1.2) are dissolved in 10 ml of ethanol and 2 ml of 1N sodium hydroxide solution are added. The mixture is stirred for 3 hours at 80° C. After cooling, 2 ml of 1N hydrochloric acid are added and the mixture is stirred for half an hour at ambient temperature. The precipitate formed is suction filtered and washed with ethanol and diethyl ether.

Provenance & Evidence