Hydrochloric Acid → HCID 178517233, compound

HRID 2109026Notes

Reaction equation

HRID 2109026 reaction equation
C([O:3][C:4]([C:6]1[CH:30]=[CH:29][C:9]([NH:10]/[C:11](=[C:18]2\[C:19](=[O:28])[NH:20][C:21]3[C:26]\2=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=3)/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[C:4]([C:6]1[CH:30]=[CH:29][C:9]([NH:10]/[C:11](=[C:18]2\[C:19](=[O:28])[NH:20][C:21]3[C:26]\2=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=3)/[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:8][CH:7]=1)([OH:5])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178469017HCID 178469017, compound

Product 1

HCID 178517233HCID 178517233, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

450 mg of 3-Z-[1-(4-ethoxycarbonyl-anilino)-1-phenyl-methylene]-6-chloro-2-indolinone (educt 1.2) are dissolved in 10 ml of ethanol and 2 ml of 1N sodium hydroxide solution are added. The mixture is stirred for 3 hours at 80° C. After cooling, 2 ml of 1N hydrochloric acid are added and the mixture is stirred for half an hour at ambient temperature. The precipitate formed is suction filtered and washed with ethanol and diethyl ether.

Workup

  1. temperatureAfter cooling
  2. stirringthe mixture is stirred for half an hour at ambient temperature
  3. customThe precipitate formed
  4. filtrationfiltered
  5. washwashed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-a5b1bde519f74194b533081d13c791a1
Source dataset
uspto-grants-2009_04
Patent number
US07514468B2

Reaction notes

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