Propylamine → HCID 11313417, compound

HRID 2109089Notes

Reaction equation

HRID 2109089 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][CH2:15][CH3:16])[CH2:10][C:11]([OH:13])=O)=[CH:5][C:4]=1[C:17]([F:20])([F:19])[F:18])#[N:2].[CH2:21]([NH2:24])[CH2:22][CH3:23]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][CH2:15][CH3:16])[CH2:10][C:11]([NH:24][CH2:21][CH2:22][CH3:23])=[O:13])=[CH:5][C:4]=1[C:17]([F:20])([F:19])[F:18])#[N:2]

Participants

3

Reactant 2

HCID 7852PropylamineHCID 11243130HCID 11243130, compound

Product 1

HCID 11313417HCID 11313417, compound

Procedure

Synthesized as described in example 3 using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-propylglycine and propylamine: 1H NMR (400 MHz, CDCl3) δ 7.61 (d, J=8.6 Hz, 1H), 6.92 (d, J=2.5 Hz, 1H), 6.76 (dd, J=8.8, 2.5 Hz, 1H), 5.94 (bs, 1H), 3.98 (s, 2H), 3.41 (t, J=7.9 Hz, 2H), 3.22 (q, J=6.8 Hz, 2H), 1.68 (m, 2H), 1.45 (m, 2H), 0.99 (t, J=7.3 Hz, 3H), 0.82 (t, J=7.5 Hz, 3H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-f6ddf64016ac4fe397bfda4c3994687a
Source dataset
uspto-grants-2009_04
Patent number
US07514470B2

Reaction notes

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