Tert-Butylamine → 1-tert-butyl-1H-imidazole-5-carbaldehyde

HRID 2109233Notes

Reaction equation

Cl.C(=N)OCC.[C:7]([NH2:11])([CH3:10])([CH3:9])[CH3:8].C1(N2[C:19]([CH:20]=[O:21])=[CH:18][N:17]=[C:16]2C)CC1>>[C:7]([N:11]1[C:19]([CH:20]=[O:21])=[CH:18][N:17]=[CH:16]1)([CH3:10])([CH3:9])[CH3:8]

Participants

Reactant 3

HCID 6385Tert-Butylamine

HCID 12578842Ethyl formimidate hydrochloride

HCID 210973073-cyclopropyl-2-methyl-3H-imidazole-4-carbaldehyde

Product 1

HCID 210973151-tert-butyl-1H-imidazole-5-carbaldehyde

Procedure

3-tert-Butyl-3H-imidazole-4-carbaldehyde was prepared from ethyl formimidate hydrochloride (Aldrich) and tert-butylamine in the same manner as 3-cyclopropyl-2-methyl-3H-imidazole-4-carbaldehyde (Example 45).

Sources & evidence

ORD record: ord-a8ec3e3be2844535994be8ce7be9a2a3
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07514458B2

Reaction notes

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