4,5-Dihydro-2-thiazolamine → 2,3-Dihydro-imidazo[2,1-b]thiazole-5-carbaldehyde

HRID 2109236Notes

Reaction equation

HRID 2109236 reaction equation
[S:1]1[CH2:5][CH2:4][N:3]=[C:2]1[NH2:6].Br[C:8](=[CH:11]OC(C)C)[CH:9]=[O:10].C1(N2C(C=O)=CN=C2C)CC1>>[S:1]1[CH2:5][CH2:4][N:3]2[C:8]([CH:9]=[O:10])=[CH:11][N:6]=[C:2]12

Participants

4

Reactant 3

HCID 156894,5-Dihydro-2-thiazolamineHCID 210973073-cyclopropyl-2-methyl-3H-imidazole-4-carbaldehydeHCID 534166342-Bromo-3-isopropoxy-propenal

Product 1

HCID 210972542,3-Dihydro-imidazo[2,1-b]thiazole-5-carbaldehyde

Procedure

2,3-Dihydro-imidazo[2,1-b]thiazole-5-carbaldehyde was prepared from 4,5-dihydro-thiazol-2-ylamine and and 2-bromo-3-isopropoxy-propenal in the same manner as cyclopropyl-2-methyl-3H-imidazole-4-carbaldehyde (Example 45).

Sources & evidence

ORD record
ord-1e6ee11fa4034a43a85dafb002eb883f
Source dataset
uspto-grants-2009_04
Patent number
US07514458B2

Reaction notes

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