Ethyl Acetoacetate → 1-Cyclohexyl-5-methyl-1H-pyrazole-4-carbaldehyde

HRID 2109254Notes

Reaction equation

[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=O.C1(NN)CCCCC1.[CH:18]1([C:21]2[N:25]([CH:26](C)C)[N:24]=[CH:23][C:22]=2C=O)[CH2:20][CH2:19]1>>[CH:23]1([N:24]2[C:3]([CH3:5])=[C:2]([CH:1]=[O:7])[CH:26]=[N:25]2)[CH2:19][CH2:20][CH2:18][CH2:21][CH2:22]1

Participants

Reactant 3

HCID 8868Ethyl Acetoacetate

HCID 80993Cyclohexylhydrazine

HCID 196201355-cyclopropyl-1-(propan-2-yl)-1H-pyrazole-4-carbaldehyde

Product 1

HCID 210972391-Cyclohexyl-5-methyl-1H-pyrazole-4-carbaldehyde

Procedure

1-Cyclohexyl-5-methyl-1H-pyrazole-4-carbaldehyde was prepared from ethyl acetoacetate and cyclohexyl hydrazine (TCI) in the same manner as 5-cyclopropyl-1-isopropyl-1H-pyrazole-4-carbaldehyde (Example 49).

Sources & evidence

ORD record: ord-508eb9ec947c4c329464ace4d6653b1e
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07514458B2

Reaction notes

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