HRID2109306

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID600637

2-Methoxy-5-(trifluoromethyl)aniline

C8H8F3NO

结构：CCc1c(-c2cn(-c3cc(C(=O)OC)ccc3C)cn2)cnn1-c1ccccc1

HCID58861445

未命名化合物

PRODUCTS

生成物

结构：CCc1c(-c2cn(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4OC)ccc3C)cn2)cnn1-c1ccccc1

HCID21097092

未命名化合物

PROCEDURE

实验过程

Example 154 was prepared from 2-methoxy-5-trifluoromethyl-phenylamine and 3-[4-(5-ethyl-1-phenyl-1H-pyrazol-4-yl)-imidazol-1-yl]-4-methyl-benzoic acid methyl ester (Example 151) in the same manner as Example 151. ESI MS m/z 546 [C30H26F3N5O2+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-63178c02de024c15946453da0a69554c
来源数据集: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07514458B2
来源说明: uspto-grants-2009_04

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[NH2:13].C[O:15][C:16](=O)[C:17]1[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([N:24]2[CH:28]=[C:27]([C:29]3[CH:30]=[N:31][N:32]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)[C:33]=3[CH2:34][CH3:35])[N:26]=[CH:25]2)[CH:18]=1>>[CH2:34]([C:33]1[N:32]([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[N:31]=[CH:30][C:29]=1[C:27]1[N:26]=[CH:25][N:24]([C:19]2[CH:18]=[C:17]([CH:22]=[CH:21][C:20]=2[CH3:23])[C:16]([NH:13][C:4]2[CH:5]=[C:6]([C:9]([F:11])([F:10])[F:12])[CH:7]=[CH:8][C:3]=2[O:2][CH3:1])=[O:15])[CH:28]=1)[CH3:35]