Hydrazine hydrate (1:1) → HCID 12703010, compound

HRID 2109375Notes

Reaction equation

HRID 2109375 reaction equation
[C:1]1([C:7]2[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:10][O:9][C:8]=2[C:18]([O:20]C)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:23][NH2:24]>C(O)C>[C:1]1([C:7]2[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:10][O:9][C:8]=2[C:18]([NH:23][NH2:24])=[O:20])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 162667Methyl 3,4-diphenyl-2-furoate

Product 1

HCID 12703010HCID 12703010, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethanol (50 ml) was added to a mixture of methyl 3,4-diphenyl-2-furancarboxylate (14.00 g) and hydrazine monohydrate (7.33 ml), and heated at reflux while stirring overnight. After concentrating the reaction solution under reduced pressure and adding ethanol, the thus-precipitated crystals were filtered, thereby giving 13.80 g of the desired compound.

Workup

  1. temperatureheated
  2. temperatureat reflux
  3. concentrationAfter concentrating the reaction solution under reduced pressure
  4. additionadding ethanol
  5. filtrationthe thus-precipitated crystals were filtered

Sources & evidence

ORD record
ord-f5605ecc54ed48d3a8023b02ebf44554
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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