HCID 23062455, compound → HCID 23062408, compound

HRID 2109378Notes

Reaction equation

HRID 2109378 reaction equation
[C:1]1([C:7]2[C:8]([CH:16]=[CH2:17])=[C:9]([C:12]([O:14][CH3:15])=[O:13])[O:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[C].[Pd].C(O)C>[CH2:16]([C:8]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:11][O:10][C:9]=1[C:12]([O:14][CH3:15])=[O:13])[CH3:17]

Participants

4

Reactant 1

HCID 23062455HCID 23062455, compound

Product 1

HCID 23062408HCID 23062408, compoundYield 99.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

An ethanol (10 ml) solution of methyl 4-phenyl-3-vinyl-2-furancarboxylate (0.20 g) was blended with 10% palladium carbon and hydrogenated for 3 hours at 25° C. while stirring. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure, thereby giving 0.20 g of methyl 3-ethyl-4-phenyl-2-furancarboxylate. This compound was reacted with hydrazine monohydrate in the same manner as in Reference Example 31, thereby giving 0.12 g of the desired compound.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-cb01beee402c420796cbcbb9d8756219
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

Loading…