3-Bromo-4-methoxybenzoic acid → Ethyl 3-bromo-4-methoxybenzoate

HRID 2109390Notes

Reaction equation

HRID 2109390 reaction equation
Br[C:2]1C=CO[C:3]=1C(O)=O.[Br:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[C:14]([OH:16])=[O:15]>>[Br:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[C:14]([O:16][CH2:2][CH3:3])=[O:15]

Participants

3

Reactant 2

HCID 668363-Bromo-4-methoxybenzoic acidHCID 6054793-Bromofuran-2-carboxylic acid

Product 1

HCID 23062539Ethyl 3-bromo-4-methoxybenzoate

Procedure

A reaction was carried out in the same manner as in Reference Example 1 except that the 3-bromo-2-furancarboxylic acid used in Reference Example 1 was replaced with 3-bromo-4-methoxybenzoic acid (4.62 g). The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1/10), thereby giving 4.65 g of ethyl 3-bromo-4-methoxybenzoate.

Workup

  1. customThe crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1/10)

Sources & evidence

ORD record
ord-4b46e69b70fd4b4aa893cbd58bfefb1d
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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