反应详情

温度

25 °C

Acetic anhydride (550 ml) was added to a mixture of 4-hydroxy-3-nitrobenzoic acid (100 g) and pyridine (119.82 ml), and stirred for 3 hours at 25° C. The reaction solution was poured into a cooled hydrochloric acid solution, and the thus-precipitated crystals were filtered and washed with cold water. The crystals were recrystallized from ethyl acetate/hexane, thereby giving 85.45 g of the desired compound.

1. filtrationthe thus-precipitated crystals were filtered
2. washwashed with cold water
3. customThe crystals were recrystallized from ethyl acetate/hexane