Hydrochloric Acid → HCID 68863922, compound

HRID 2109396Notes

Reaction equation

HRID 2109396 reaction equation
[C:1]([O:5][C:6]([C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[OH:18])[C:11]([O:13]C)=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>O1CCOCC1>[C:1]([O:5][C:6]([C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[OH:18])[C:11]([OH:13])=[O:12])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23062509HCID 23062509, compound

Product 1

HCID 68863922HCID 68863922, compoundYield 82.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a mixture of 1.00 g of the methyl 3-tert-butyloxycarbonyl-4-hydroxybenzoate and dioxane (10 ml) was added a 1 M aqueous sodium hydroxide solution (16 ml) at 25° C. and stirred overnight. The reaction solution was neutralized with 1 M hydrochloric acid, extracted with ethyl acetate, and dried over MgSO4. The solvent was evaporated under reduced pressure, thereby giving 0.78 g of 3-tert-butyloxycarbonyl-4-hydroxybenzoic acid.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialdried over MgSO4
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-0e44d1894d6e4d4eb5bc4e0adcfb4b03
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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