Ethyl Acetate → HCID 86600023, compound

HRID 2109399Notes

Reaction equation

HRID 2109399 reaction equation
[CH3:1][C:2]1[C:24]([CH3:25])=[CH:23][C:22]([CH3:26])=[C:21]([CH3:27])[C:3]=1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:16]=[CH:15][O:14][C:13]=1[C:17]([NH:19][NH2:20])=[O:18].C([O:31][CH2:32][CH3:33])(=O)C>>[C:17]([C:13]1[CH:12]=[C:7]([CH:8]=[CH:33][C:32]=1[OH:31])[C:6]([NH:20][NH:19][C:17]([C:13]1[O:14][CH:15]=[CH:16][C:12]=1[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[O:5][CH2:4][C:3]1[C:21]([CH3:27])=[C:22]([CH3:26])[CH:23]=[C:24]([CH3:25])[C:2]=1[CH3:1])=[O:18])=[O:5])#[N:19]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 86600024HCID 86600024, compound

Product 1

HCID 86600023HCID 86600023, compound

Procedure

In ethyl acetate (10 ml), a mixture composed of 3-[2-(2,3,5,6-tetramethylbenzyloxy)phenyl]-2-furancarboxylic acid hydrazide (compound of Reference Example 6, 0.36 g) and the compound of Reference Example 63 (0.33 g) was heated at reflux overnight while stirring. The thus-precipitated crystals were filtered and recrystallized from ethyl acetate, thereby giving 0.18 g of the desired compound. Melting point: 215-217° C.

Workup

  1. temperatureat reflux overnight
  2. filtrationThe thus-precipitated crystals were filtered
  3. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-97df5dc2ad1448c2ad710118b5dbbe76
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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