Water → HCID 68862895, compound

HRID 2109400Notes

Reaction equation

HRID 2109400 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:19]=[CH:18][O:17][C:16]=2[C:20]([NH:22][NH2:23])=[O:21])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH2:24].C([O:28][CH2:29][CH3:30])(=O)C>>[C:20]([C:16]1[CH:15]=[C:12]([CH:11]=[CH:30][C:29]=1[OH:28])[C:13]([NH:23][NH:22][C:20]([C:16]1[O:17][CH:18]=[CH:19][C:15]=1[C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:10][CH:11]=1)=[O:21])=[O:24])#[N:22]

Participants

4

Reactant 3

HCID 962WaterHCID 8857Ethyl AcetateHCID 68862090HCID 68862090, compound

Product 1

HCID 68862895HCID 68862895, compound

Procedure

A mixture of 3-(4-benzyloxyphenyl)-2-furancarboxylic acid hydrazide (compound of Reference Example 79, 0.44 g) and the compound of Reference Example 63 (0.50 g) in ethyl acetate (10 ml) was heated at reflux overnight while stirring. Water was added to the reaction solution, and the thus-precipitated crystals were collected by filtration and recrystallized from ethyl acetate, thereby giving 0.29 g of the desired compound. Melting point: 208-209° C.

Workup

  1. temperatureat reflux overnight
  2. filtrationthe thus-precipitated crystals were collected by filtration
  3. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-c8595662ed2548519618ec820fbb511d
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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