Ethyl Acetate → HCID 11517437, compound

HRID 2109401Notes

Reaction equation

HRID 2109401 reaction equation
[C:1]1([C:7]2[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:10][O:9][C:8]=2[C:18]([NH:20][NH2:21])=[O:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O:25][CH2:26][CH3:27])(=O)C>>[C:18]([C:8]1[CH:7]=[C:11]([CH:12]=[CH:27][C:26]=1[OH:25])[C:10]([NH:21][NH:20][C:18]([C:8]1[O:9][CH:10]=[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:7]=1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:19])=[O:9])#[N:20]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 12703010HCID 12703010, compound

Product 1

HCID 11517437HCID 11517437, compound

Procedure

A mixture of 3,4-diphenyl-2-furancarboxylic acid hydrazide (compound of Reference Example 32, 5.2 g) and the compound of Reference Example 63 (6.1 g) in ethyl acetate (10 ml) was heated at reflux overnight while stirring. The thus-precipitated crystals were collected by filtration and recrystallized from ethyl acetate/diisopropyl ether, thereby giving 5.1 g of the desired compound. Melting point: 178-179° C.

Workup

  1. temperatureat reflux overnight
  2. filtrationThe thus-precipitated crystals were collected by filtration
  3. customrecrystallized from ethyl acetate/diisopropyl ether

Sources & evidence

ORD record
ord-21206b67551849278e12dbf75cf31f49
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

Loading…