Ethyl Acetate → HCID 68862885, compound

HRID 2109408Notes

Reaction equation

HRID 2109408 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[C:11]([C:14]([NH:16][NH2:17])=[O:15])[O:12][CH:13]=2)=[CH:5][CH:4]=1.C([O:27][CH2:28][CH3:29])(=O)C>>[C:14]([C:11]1[CH:10]=[C:9]([CH:6]=[CH:29][C:28]=1[OH:27])[C:13]([NH:17][NH:16][C:14]([C:11]1[O:12][CH:13]=[C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[C:10]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=[O:12])#[N:16]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 68864257HCID 68864257, compound

Product 1

HCID 68862885HCID 68862885, compound

Procedure

A mixture of 4-(4-methoxyphenyl)-3-phenyl-2-furancarboxylic acid hydrazide (compound of Reference Example 10, 0.31 g) and the compound of Reference Example 63 (0.33 g) in ethyl acetate (10 ml) was heated at reflux while stirring overnight. The thus-precipitated crystals were collected by filtration and recrystallized from ethyl acetate/diisopropyl ether, thereby giving 0.31 g of the desired compound. Melting point: 146-148° C.

Workup

  1. temperatureat reflux
  2. filtrationThe thus-precipitated crystals were collected by filtration
  3. customrecrystallized from ethyl acetate/diisopropyl ether

Sources & evidence

ORD record
ord-07b8ba7d898247f9aa8e5af1910f1c68
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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