Ethyl Acetate → HCID 68862165, compound

HRID 2109409Notes

Reaction equation

HRID 2109409 reaction equation
[C:1]1([C:7]2[C:11]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[CH:10][O:9][C:8]=2[C:18]([NH:20][NH2:21])=[O:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O:25][CH2:26][CH3:27])(=O)C>>[C:14]([C:13]1[CH:12]=[C:11]([CH:7]=[CH:27][C:26]=1[OH:25])[C:10]([NH:21][NH:20][C:18]([C:8]1[O:9][CH:10]=[C:11]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[C:7]=1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:19])=[O:9])#[N:15]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 68985624HCID 68985624, compound

Product 1

HCID 68862165HCID 68862165, compound

Procedure

A mixture of 3-phenyl-4-(4-pyridyl)-2-furancarboxylic acid hydrazide (compound of Reference Example 11, 0.28 g) and the compound of Reference Example 63 (0.33 g in ethyl acetate (10 ml) was heated at reflux while stirring overnight. The thus-precipitated crystals were collected by filtration and recrystallized from ethyl acetate, thereby giving 0.02 g of the desired compound. Melting point: 179-181° C.

Workup

  1. temperatureat reflux
  2. filtrationThe thus-precipitated crystals were collected by filtration
  3. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-bf17dc303fb848d4a5874ee601dbd1db
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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