AR-R-17779 → (R)-3'-[2-(3-Pyridyl)thiophen-4-yl]spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one

HRID 2109446노트

반응식

HRID 2109446 반응식
[O:1]1[C@@:5]2([CH:10]3[CH2:11][CH2:12][N:7]([CH2:8][CH2:9]3)[CH2:6]2)[CH2:4][NH:3][C:2]1=[O:13].Br[C:15]1[CH:16]=[C:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[S:18][CH:19]=1>>[N:22]1[CH:23]=[CH:24][CH:25]=[C:20]([C:17]2[S:18][CH:19]=[C:15]([N:3]3[CH2:4][C@:5]4([CH:10]5[CH2:11][CH2:12][N:7]([CH2:8][CH2:9]5)[CH2:6]4)[O:1][C:2]3=[O:13])[CH:16]=2)[CH:21]=1

참가 물질

3

반응물 2

HCID 5310971AR-R-17779HCID 221807813-(4-bromo-2-thienyl)Pyridine

생성물 1

HCID 11325305(R)-3'-[2-(3-Pyridyl)thiophen-4-yl]spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one

실험 절차

The title compound was prepared by a method analogous to that described in Preparation 3 from (S)-spiro[1-azabicyclo[2.2.2]octan-3,5′-oxazolidin]-2′-one and 4-bromo-2-(3-pyridyl)thiophene. The title compound (800 mg) was obtained as a pale-yellow solid, m/z 342 (MH+).

후처리

  1. customThe title compound was prepared by a method analogous to

출처 및 근거

ORD 기록
ord-062cd926fe83459880549e568219071a
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07514567B2

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