HuagongsheHuagongshe Chemistry Print Report · For research reference only
AR-R-17779 → (R)-3'-[5-(4-Pyridyl)-1,3,4-thiadiazol-2-yl]spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | AR-R-17779 | HCID 5310971 | — |
| Reactant | 4-(5-Bromo-1,3,4-thiadiazol-2-yl)pyridine | HCID 57634262 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | (R)-3'-[5-(4-Pyridyl)-1,3,4-thiadiazol-2-yl]spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one | HCID 57634239 | — |
Reaction Steps
The compound was prepared by a method analogous to that described in Preparation 3 from (S)-spiro[1-azabicyclo[2.2.2]octan-3,5′-oxazolidin]-2′-one and 2-bromo-5-(4-pyridyl)-1,3,4-thiadiazole using 5 equivalents of copper (I) iodide. The title compound was obtained as a beige solid, m/z 344 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07514567B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-6cd73dd400094eafb4407b0753ba021b |
| Source note | uspto-grants-2009_04 |