HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-(5-Trifluoromethylpyridin-2-yl)azetidin-3-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | [1-(5-Trifluoromethylpyridin-2-yl)azetidin-3-yl]carbamic acid t-butyl ester | HCID 69055899 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(5-Trifluoromethylpyridin-2-yl)azetidin-3-ylamine | HCID 10082062 | 92.9% |
Reaction Steps
D6 (750 mg, 1.28 mM) in dichloromethane (5 ml) was treated with trifluoroacetic acid (5 ml) overnight at ambient temperature. The solution was concentrated and then partitioned between dichloromethane and 2M sodium hydroxide. The dichloromethane solution was washed with brine, dried and concentrated to give the title compound as a colourless solid, (477 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07514562B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-8e1d532e6c224ff0bccba3248ad38f9a |
| Source note | uspto-grants-2009_04 |