2-Bromophenyl isocyanate → N-(2-Bromophenyl)-N'-[(1-(5-trifluoromethyl-2-pyridyl)azetidin-3-yl)]urea

HRID 2109516Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2109516
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:12][CH:11]([NH2:13])[CH2:10]2)=[N:7][CH:8]=1.[Br:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]=[C:24]=[O:25]>ClCCl>[Br:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH:23][C:24]([NH:13][CH:11]1[CH2:10][N:9]([C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:14])[F:15])=[CH:8][N:7]=2)[CH2:12]1)=[O:25]

Komponenten

4

Edukt 2

HCID 1370972-Bromophenyl isocyanateHCID 100820621-(5-Trifluoromethylpyridin-2-yl)azetidin-3-ylamine

Produkt 1

HCID 10476923N-(2-Bromophenyl)-N'-[(1-(5-trifluoromethyl-2-pyridyl)azetidin-3-yl)]ureaAusbeute 83,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

D7 (100 mg, 0.46 mmol) in dichloromethane (2 ml) at ambient temperature was treated with 2-bromophenyl isocyanate (91 mg, 0.46 mmol) in dichloromethane (1 ml). The reaction mixture was maintained at ambient temperature overnight. The white solid was removed by centrifugation and washed with diethyl ether, and dried in vacuo, to give the title compound, (160 mg). MH+ 415, 417.

Aufarbeitung

  1. customThe white solid was removed by centrifugation
  2. washwashed with diethyl ether
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6f3e41cab6354498aaaaf5f14812e953
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07514562B2

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