HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromophenyl isocyanate → N-(2-Bromophenyl)-N'-[(1-(5-trifluoromethyl-2-pyridyl)azetidin-3-yl)]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromophenyl isocyanate | HCID 137097 | — |
| Reactant | 1-(5-Trifluoromethylpyridin-2-yl)azetidin-3-ylamine | HCID 10082062 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-Bromophenyl)-N'-[(1-(5-trifluoromethyl-2-pyridyl)azetidin-3-yl)]urea | HCID 10476923 | 83.8% |
Reaction Steps
D7 (100 mg, 0.46 mmol) in dichloromethane (2 ml) at ambient temperature was treated with 2-bromophenyl isocyanate (91 mg, 0.46 mmol) in dichloromethane (1 ml). The reaction mixture was maintained at ambient temperature overnight. The white solid was removed by centrifugation and washed with diethyl ether, and dried in vacuo, to give the title compound, (160 mg). MH+ 415, 417.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07514562B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-6f3e41cab6354498aaaaf5f14812e953 |
| Source note | uspto-grants-2009_04 |