反应详情

D4 (73 mg, 0.46 mmol) in dry dichloromethane (5 ml) was treated with pyridine (45 ul, 0.55 mmol) and phenyl chloroformate (69 ul, 0.55 mmol). After 1 h triethylamine (128 ul, 0.92 mmol) was added, followed by D7 (100 mg, 0.46 mmol). The reaction mixture was then stirred overnight at ambient temperature. The precipitate was separated by centrifugation, washed with dichloromethane then diethyl ether and then dried to give the title compound as a yellow solid (129 mg). MH+ 402.

1. customThe precipitate was separated by centrifugation
2. washwashed with dichloromethane
3. dry with materialdiethyl ether and then dried