反应详情

A mixture of 2.21 g of 1-cyclopropyl-3-(2-nitrophenyl)-propan-1-ol (10 mmol), 1.21 g of triethylamine (12 mmol) and 20 ml of dichloromethane is cooled to a temperature of 5° C. and 1.26 g of methanesulfonic acid chloride (11 mmol), dissolved in 5 ml of dichloromethane, are added dropwise. The resulting mixture is stirred for 16 hours at ambient temperature. The organic phase is washed with ice-water and dried over sodium sulfate and concentrated by evaporation. 1-Cyclopropyl-3-(2-nitrophenyl)-propyl methanesulfonate is obtained in the form of a crude product, which is used directly in the cyclisation.

1. additionare added dropwise
2. washThe organic phase is washed with ice-water
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated by evaporation