3-Nitrobenzenesulfonyl chloride → HCID 9871166, compound

HRID 2109544Notes

Reaction equation

HRID 2109544 reaction equation
[CH2:1]([NH:9][C:10]([C:12]1[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:24][NH2:25])=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[N+:26]([C:29]1[CH:30]=[C:31]([S:35](Cl)(=[O:37])=[O:36])[CH:32]=[CH:33][CH:34]=1)([O-:28])=[O:27].C(NC(C1C(C2C=CC=CC=2C(S(C2C=CC=C([N+]([O-])=O)C=2)(=O)=O)N)=CC=CC=1)=O)CC1C=CC=CC=1>>[CH2:1]([NH:9][C:10]([C:12]1[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:24][NH:25][S:35]([C:31]2[CH:32]=[CH:33][CH:34]=[C:29]([N+:26]([O-:28])=[O:27])[CH:30]=2)(=[O:36])=[O:37])=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11])[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 84763-Nitrobenzenesulfonyl chlorideHCID 155093842'-(Aminomethyl)-N-(2-phenylethyl)[1,1'-biphenyl]-2-carboxamideHCID 68973753HCID 68973753, compound

Product 1

HCID 9871166HCID 9871166, compound

Procedure

From 0.61 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid phenethylamide (precursor 5a) and 3-nitrophenylsulfonyl chloride, according to the general working procedure 272 mg of 2′-(3-nitrophenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid phenethylamide were obtained; m.p. 145° C. MS (ES+): m/e=516 (M+1).

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-5ababc9a6d6d4c33848d648405aa1796
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

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