4-Ethylbenzene-1-sulfonyl chloride → HCID 9870530, compound

HRID 2109546Notes

Reaction equation

HRID 2109546 reaction equation
[CH2:1]([NH:9][C:10]([C:12]1[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:24][NH2:25])=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:26]([C:28]1[CH:33]=[CH:32][C:31]([S:34](Cl)(=[O:36])=[O:35])=[CH:30][CH:29]=1)[CH3:27].C(NC(C1C(C2C=CC=CC=2C(S(C2C=CC(CC)=CC=2)(=O)=O)N)=CC=CC=1)=O)CC1C=CC=CC=1>>[CH2:1]([NH:9][C:10]([C:12]1[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:24][NH:25][S:34]([C:31]2[CH:32]=[CH:33][C:28]([CH2:26][CH3:27])=[CH:29][CH:30]=2)(=[O:36])=[O:35])=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11])[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 5709594-Ethylbenzene-1-sulfonyl chlorideHCID 155093842'-(Aminomethyl)-N-(2-phenylethyl)[1,1'-biphenyl]-2-carboxamideHCID 68968595HCID 68968595, compound

Product 1

HCID 9870530HCID 9870530, compound

Procedure

From 0.61 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid -phenethylamide (precursor 5a) and 4-ethylphenylsulfonyl chloride, according to the general working procedure 250 mg of 2′-(4-ethylphenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid phenethylamide were obtained;

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-3bef3afe6cb045bd8d2de0c2959ef7be
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

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