3-(Trifluoromethyl)benzenesulfonyl chloride → 2'-(3-Trifluoromethylphenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide

HRID 2109547Notes

Reaction equation

HRID 2109547 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH2:23][NH2:24])=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:25][C:26]([F:38])([F:37])[C:27]1[CH:28]=[C:29]([S:33](Cl)(=[O:35])=[O:34])[CH:30]=[CH:31][CH:32]=1>>[CH2:1]([NH:8][C:9]([C:11]1[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH2:23][NH:24][S:33]([C:29]2[CH:30]=[CH:31][CH:32]=[C:27]([C:26]([F:25])([F:37])[F:38])[CH:28]=2)(=[O:35])=[O:34])=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 155093852'-Aminomethylbiphenyl-2-carboxylic acid benzylamide

Product 1

HCID 98068302'-(3-Trifluoromethylphenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide

Procedure

From 0.28 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid benzylamide (precursor 5 b) and 3-trifluoromethylphenylsulfonyl chloride, according to the general working procedure 131 mg of 21-(3-trifluoromethylphenyl-sulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide were obtained; m.p. 126° C. MS (ES+): m/e=525 (M+1).

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-ec5e71787354409a9a9ef74f2119e86c
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

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