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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2109547Generated: October 30, 2026

3-(Trifluoromethyl)benzenesulfonyl chloride → 2'-(3-Trifluoromethylphenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide

https://huagongshe.com/reaction/2109547

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)benzenesulfonyl chlorideHCID 2733250—
Reactant2'-Aminomethylbiphenyl-2-carboxylic acid benzylamideHCID 15509385—
Product2'-(3-Trifluoromethylphenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamideHCID 9806830—

Reaction Steps

From 0.28 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid benzylamide (precursor 5 b) and 3-trifluoromethylphenylsulfonyl chloride, according to the general working procedure 131 mg of 21-(3-trifluoromethylphenyl-sulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide were obtained; m.p. 126° C. MS (ES+): m/e=525 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07514582B2
Source datasetuspto-grants-2009_04
ORD IDord-ec5e71787354409a9a9ef74f2119e86c
Source noteuspto-grants-2009_04