3-Fluorobenzenesulfonyl Chloride → 2'-(3-Fluorophenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide

HRID 2109549Notes

Reaction equation

HRID 2109549 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH2:23][NH2:24])=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:25][C:26]1[CH:27]=[C:28]([S:32](Cl)(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=1.C(NC(C1C(C2C=CC=CC=2C(S(C2C=CC=C(F)C=2)(=O)=O)N)=CC=CC=1)=O)C1C=CC=CC=1>>[CH2:1]([NH:8][C:9]([C:11]1[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH2:23][NH:24][S:32]([C:28]2[CH:29]=[CH:30][CH:31]=[C:26]([F:25])[CH:27]=2)(=[O:34])=[O:33])=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 155093852'-Aminomethylbiphenyl-2-carboxylic acid benzylamideHCID 689717182'-(3-Fluorophenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid benzylamide

Product 1

HCID 98477252'-(3-Fluorophenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide

Procedure

From 0.28 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid benzylamide (precursor 5b) and 3-fluorophenylsulfonyl chloride, according to the general working procedure 112 mg of 2′-(3-fluorophenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid benzylamide were obtained;

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-03586c491d9d4ee08664e7dd86dc5f82
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

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