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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2109549Generated: October 29, 2026

3-Fluorobenzenesulfonyl Chloride → 2'-(3-Fluorophenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide

https://huagongshe.com/reaction/2109549

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluorobenzenesulfonyl ChlorideHCID 2734258—
Reactant2'-Aminomethylbiphenyl-2-carboxylic acid benzylamideHCID 15509385—
Reactant2'-(3-Fluorophenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid benzylamideHCID 68971718—
Product2'-(3-Fluorophenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamideHCID 9847725—

Reaction Steps

From 0.28 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid benzylamide (precursor 5b) and 3-fluorophenylsulfonyl chloride, according to the general working procedure 112 mg of 2′-(3-fluorophenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid benzylamide were obtained;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07514582B2
Source datasetuspto-grants-2009_04
ORD IDord-03586c491d9d4ee08664e7dd86dc5f82
Source noteuspto-grants-2009_04