4-Fluorobenzenesulfonyl chloride → HCID 9804010, compound

HRID 2109550Notes

Reaction equation

HRID 2109550 reaction equation
[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH2:21])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7].[F:23][C:24]1[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=1.CC(C)CCNC(C1C(C2C=CC=CC=2C(S(C2C=CC(F)=CC=2)(=O)=O)N)=CC=CC=1)=O>>[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH:21][S:30]([C:27]2[CH:28]=[CH:29][C:24]([F:23])=[CH:25][CH:26]=2)(=[O:32])=[O:31])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7]

Participants

4

Reactant 3

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 673161092'-Aminomethylbiphenyl-2-carboxylic acid (3-methylbutyl)amideHCID 86589513HCID 86589513, compound

Product 1

HCID 9804010HCID 9804010, compound

Procedure

From 0.34 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid (3-methyl-butyl)amide (precursor 5c) and 4-fluorophenylsulfonyl chloride, according to the general working procedure 122 mg of 2′-(4-fluorophenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid (3-methylbutyl)amide were obtained; m.p. 149° C. MS (ES+): m/e=455 (M+1).

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-d8974843d133474b908a9614e1e33b11
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

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