3-Fluorobenzenesulfonyl Chloride → HCID 9846776, compound

HRID 2109551Notes

Reaction equation

HRID 2109551 reaction equation
[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH2:21])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7].[F:23][C:24]1[CH:25]=[C:26]([S:30](Cl)(=[O:32])=[O:31])[CH:27]=[CH:28][CH:29]=1.CC(C)CCNC(C1C(C2C=CC=CC=2C(S(C2C=CC=C(F)C=2)(=O)=O)N)=CC=CC=1)=O>>[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH:21][S:30]([C:26]2[CH:27]=[CH:28][CH:29]=[C:24]([F:23])[CH:25]=2)(=[O:32])=[O:31])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7]

Participants

4

Reactant 3

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 673161092'-Aminomethylbiphenyl-2-carboxylic acid (3-methylbutyl)amideHCID 86589514HCID 86589514, compound

Product 1

HCID 9846776HCID 9846776, compound

Procedure

From 0.34 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid (3-methyl-butyl)amide (precursor 5c) and 3-fluorophenylsulfonyl chloride, according to the general working procedure 118 mg of 2′-(3-fluorophenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid (3-methylbutyl)amide were obtained; m.p. 141° C. MS (ES+): m/e=455 (M+1).

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-f9b10071d3f64b53b8c0d7e3a23eb334
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

Loading…