2-Propanesulfonyl chloride → HCID 9887383, compound

HRID 2109552Notes

Reaction equation

HRID 2109552 reaction equation
[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH2:21])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7].[CH:23]([S:26](Cl)(=[O:28])=[O:27])([CH3:25])[CH3:24]>>[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH:21][S:26]([CH:23]([CH3:25])[CH3:24])(=[O:28])=[O:27])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7]

Participants

3

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 673161092'-Aminomethylbiphenyl-2-carboxylic acid (3-methylbutyl)amide

Product 1

HCID 9887383HCID 9887383, compound

Procedure

From 0.34 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid (3-methyl-butyl)amide (precursor 5c) and isopropylsulfonyl chloride, according to the general working procedure followed by purification by flash chromatography 16 mg of 2′-(isopropylsulfonylaminomethyl)biphenyl-2-carboxylic acid (3-methylbutyl)amide were obtained as an oil. MS (ES+): m/e 403 (M+1).

Workup

  1. customfollowed by purification by flash chromatography 16 mg of 2′-(isopropylsulfonylaminomethyl)biphenyl-2-carboxylic acid (3-methylbutyl)amide
  2. customwere obtained as an oil

Sources & evidence

ORD record
ord-24b280622ef947ad85e2bf871e8cf43a
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

Loading…